Parkinson disease

QSMetric Potential Indications – Parkinson disease

Discover a potential indication of QSMetric™ technology.

Parkinson’s disease is a neurodegenerative disorder caused by the formation of a-synuclein protein aggregates in neurons and their death. Associated with this aggregation is an accumulation of intracerebral iron and induction of the neuronal death by ferroptosis mechanism. The diagnosis of this disease is generally based on signs such as tremors at rest, rigidity of the limbs, akinesia and gait disorders.

Brain imaging, usually MRI, is often limited to ruling out another etiology. Cerebral scintigraphy may reveal dopaminergic loss. Quantification of intracerebral iron accumulation by MRI and QSM, particularly in the substantia nigra, is well documented, correlates with ferroptosis and used in research to help diagnose the disease.

Caisse nationale de l’Assurance Maladie (CNAM), Data Pathologie, AMELI, Juillet 2024
Caisse nationale de l’Assurance Maladie (CNAM), Fiche « Maladie de Parkinson », Juillet 2024
Mahoney-Sanchez et al, “a-synuclein determines ferroptosis sensitivity in dopaminergic neurons via modulation of ether-phospholipid membrane composition”, Cell Report, 2022
Ravanfar et al, “Systematic Review: Quantitative Susceptibility Mapping (QSM) of Brain Iron Profile in Neurodegenerative Diseases”, Frontiers in Neuroscience, 2021